San Nutrition Fierce was specifically formulated to increase endurance and pre-workout strength levels assisting the user to lift more weight and exercise for prolonged periods without feeling fatigued.Let's run through the list of ingredients in Fierce and see how each and every one contributes to an overall ergogenic and endurance-enhancing effect. The proprietary formula consists of 5 individual categories each of them designed to work in tandem with one another.Cell Hydration MatrixOf all the ingredients seen in Fierce, creatine in its various forms is perhaps the most familiar to supplement users. Numerous studies have shown the creatine consumption leads to increased strength and athletic performance. There are several theories about how creatine works. The original theory, and perhaps still the most widely accepted, is that oral creatine supplementation increases total creatine and creatine phosphate (CrP) in human skeletal muscle. An increased muscle CrP concentration increases its availability for ATP synthesis. This additional ATP can be used by the muscle to perform work.Studies have also shown that creatine supplementation increases the glycogen content of skeletal muscle along with an increase in myosin heavy chain synthesis (Nelson et al. 2001). The increases in lean body mass associated with creatine use may be a result of creatine's ability to elevate insulin like growth factor 1 (IGF-1) in muscle tissue (Deldicque et al 2005).Why do we see Malate combined with creatine in the formulation? Malate is an intermediate in the so-called Tricarboxylic Acid Cycle (TCA). While being processed in the TCA, each kind of major fuel is converted to acetyl groups, which are handled by attachment to a particular coenzyme known as coenzyme A. Ultimately ATP is produced from another compound, NADH, generated by the TCA.Malate is dehydrogenated in the TCA cycle to oxaloacetate, the concentration of which most critically controls the rate of aerobic ATP production. During prolonged aerobic activity, and in patients suffering from malate deficiency, malate becomes depleted and the TCA is unable to produce ATP fast enough to meet the demands of working muscle. One classic disease characterized by malate deficiency is fibromyalgia: symptoms include muscular skeletal pain and fatigue. When patients suffering with this disease are given malate, their energy levels improve dramatically (Russell et al 1995).Not only will patients suffering from malate deficiency benefit from malate supplementation but also competitive athletes. Because as mentioned above, strenuous, prolonged aerobic activity depletes the body's malate stores.Creatine-Ethyl-Ester is a synthetic analog of the popular supplement creatine. The main difference between the two compounds is that the carboxylic acid group of creatine was molecularly modified through the attachment of an ester linkage. In doing this, we are able to create an organic compound that possesses both increased water sol