VPX Sports Nutrition Meltdown, 120 capsules. What's the supplement that burns fat faster than an ice cube melts in the Sahara? VPX Sports Nutrition Meltdown Extreme Weight Loss Diet Pill ® mi amigo! In a study presented at the June 2008 International Society of Sports Nutrition Conference in the beautiful Red Rock Hotel, researchers discovered that this fat-blasting supplement jacked up metabolic rate so much so that it left scientists scratching their heads as to how it compared to other popular thermogenics. That's a finding of tsunamic proportions.1 What does this mean? Think about it Sherlock. If you take VPX Sports Supplements Meltdown Extreme Weight Loss Diet Pill before training, your metabolic rate will go through the roof faster than Anderson Silva can put you in an arm bar! You'll lose fat faster and you'll get that lean physique you've always wanted. The R & D group at VPX has more ground-breaking science coming down the pike this year. So buckle your chinstraps and get ready for the ride of your thermogenic life! Hasta la vista! References 1. Astrup A, Toubro S, Cannon S, Hein P, Madsen J. Thermogenic synergism between ephedrine and caffeine in healthy volunteers: a double-blind, placebo-controlled study. Metabolism. Mar 1991;40(3):323-329. Synephrine and Methyl Synephrine: Lipolytic Potential What is Synephrine? Citrus aurantium (also known as Bitter Orange, Sour Orange, and Seville Orange) is a relatively small citrus tree about 5 meters tall with scented white flowers (Fugh-Berman and Myers, 2004). As the name implies, the fruit is quite bitter and for this reason, it is not commonly used for culinary purposes. However, the dried, entire unripe fruit of Citrus aurantium has been used as an Asian herbal medicine primarily to treat digestive problems. More specific to this article, the greatest interest recently has been in the active alkaloids of the Citrus aurantium, synephrine (oxedrine) and octopamine (Nelson et al., 2007), which are structurally similar to epinephrine and norepinephrine, respectively. Both synephrine and octopamine are considered trace endogenous bioamines, with circulating levels noted in the plasma of healthy men and women (D'Andrea et al., 2003). Synephrine has alpha-adrenergic effects and also activates beta-3 receptors (but not beta-1 or beta-2 receptors). These effects highlight the potential mechanism of action of this agent related to thermogenesis and lipolysis. Compounds contained within the Citrus aurantium, such as synephrine, have adrenergic effects that may result in lipolysis and appetite suppression (Fugh-Berman and Myers, 2004). Synephrine, Thermogenesis and Fat/Weight Loss As stated above, synephrine is a chief ingredient in many popular fat/weight loss formulas on the market today. Claims for this ingredient include "increased fat burning", "increased energy", "increased metabolism and thermogenesis", and "increase